CEACAM5 and esophageal squamous cell carcinoma: Notably, when we focused on stage I ESCC patients, our 8-miRNA signature remarkably discriminated stage I ESCC patients from healthy controls in both Beijing-1 cohort (AUC = 0.97, 95% CI:0.93–1.00, sensitivity: 0.92, specificity: 0.92) and Beijing-2 cohorts (AUC = 0.89, 95% CI: 0.77–1.00, sensitivity: 92%, specificity: 90%); and in each instance its performance was substantially superior to that of SCC-Ag and CEA, which are routinely analyzed in clinical settings (Table S7, Fig. 4C and D, all p < 0.05, DeLong’s tests).