As the most potent antigen-presenting cells (APCs), dendritic cells (DCs) are central to the initiation and regulation of innate and adaptive immunity in the tumor microenvironment (TME), with the ability to present tumor-associated antigens (TAAs) on MHC molecules and provide costimulatory/soluble factors to shape antitumor T cell responses [1]. Here, HLA-C is linked to neoplasm.