The results showed a significant increase in the level of IGFBP-4 in people with DN (795.61 ± 130 ng/ml) compared to both, people with T2D (374.56 ± 86.8 ng/ml, p = 0.013) and non-diabetic group (273.06 ± 27.8 ng/ml, p = 0.003) (Table 1, Fig. 1D). This evidence concerns the gene IGFBP4 and liver dysplastic nodule.