IGFBP1 and liver dysplastic nodule: In the case of IGFBP-1, the data showed a significant negative correlation with both sCr (ρ = − 0.249, p <  0.05) and BUN (ρ = − 0.371, p <  0.001) in people with DN, whereas eGFR showed no association with IGFBP-1 in the same group (Table 3).