In particular, our findings indicate that AC5 inhibition in BO mice has a cardioprotective effect mediated at least in part by a decrease of NOX4 overexpression and CaMKII phosphorylation, leading to reduced phospholamban phosphorylation on serine-16 and threonine-17 (Fig. 7). This evidence concerns the gene ADCY5 and bronchiolitis obliterans syndrome.