This study aims to investigate the effect of UTI combined with TM on endotoxin-induced liver and kidney injury, and whether the combination therapy exerts its function on liver and kidney injury via inhibiting cell apoptosis, promoting cell proliferation, reducing certain inflammatory mediators, inhibiting HMGB1/TLR4/NF-κB Signal transduction, inhibiting the occurrence of oxidative stress. Here, TLR4 is linked to bacterial urinary tract infection.