Interestingly, the NLRP3 inflammasome is capable of mediating the production of apoptosis and inflammation-related proteins to participate in hypertension-induced end-organ damage [10,11] Moreover, NLRP3 is attributed to the inflammatory response in fibrosis of numerous organs, including the liver, kidney, lung, and heart [12–15]. This evidence concerns the gene NLRP3 and Hypertension.