Likewise, diffuse gliomas release various extracellular effectors such as glutamate (an excitotoxic neurotransmitter)18 or growth factors like BDNF, a potentiator of long term memory at the synaptic level.19 They form hybride tumor-astrocyte junctions that allow the passage of tumor metabolites, Calcium ions, and miRNA towards these cells.20 Such mechanisms alter astrocytic networks and neuronal synaptic organization21–23 and could in theory account for cognitive function disturbances. This evidence concerns the gene BDNF and neoplasm.