We found that 2 days of chronic 100 nM oAβ exposure resulted in a 25.77 ± 5.23% reduction in TTL content (Fig. 6A), similar to what we observed in sporadic and familial Alzheimer’s disease samples (Figs 3B and 4A and C). The gene discussed is TTL; the disease is early-onset autosomal dominant Alzheimer disease.