Interestingly, we found that Alzheimer’s disease neurons with relatively low levels of phospho-tau, and thus presumably at an early stage of the degeneration process, were significantly enriched in detyrosinated and Δ2 tubulins compared to non-diseased neurons (Fig. 3I, ****P < 0.0001 for each). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.