These memory tests were selected because they broadly assess function of cognitive domains that correlate with neural circuitry disrupted early in Alzheimer’s disease, including the hippocampus,86 and have been useful to reveal memory defects in preclinical models of β-amyloidosis and tauopathy.87,88TTL+/− mice exhibited robust deficits in spontaneous alternation in Y-maze (20.36 ± 0.91 versus 25.50 ± 1.09 number of entries and 68.44 ± 2.13 versus 51.88 ± 2.29% of alternation for wild-type and TTL+/− mice, respectively) (Fig. 1D). Here, TTL is linked to tauopathy.