It is also possible that Ncam1 elevation is more associated with axonal phenotypes in mouse model, given that our patients have a relatively advanced neuropathy (CMTES; 14.5 ± 3.3, mean ± SD), while in the C61 het mice the neuropathy starts at 2 months and progresses until 10 months of age. The gene discussed is NCAM1; the disease is neuropathy.