Diagnostic capacity of GDF15 for CMT1A (AUC 0.973, Supplementary Fig. 6) is higher than for plasma TMPRSS5 (AUC 0.913)20 and miRNAs miR-206 (AUC 0.848), miR-133a (AUC 0.773), miR-223-3p (AUC 0.738).86 NEFL is increased in a broad range of neurodegenerative diseases and less specific for CMT (AUC = 0.755). Here, GDF15 is linked to neurodegenerative disease.