NCAM1 and neuropathy: Serum NCAM1 concentrations are significantly (P = 0.016) higher in CMT patients with severe neuropathy (CMTES ≥ 10), at 61.3 ng/ml, compared to those with mild neuropathy (CMTES < 10), at 47.6 ng/ml; an increase of 28.7% (Fig. 3E).