Ncam1 elevation in mouse models coincided with the development of neuropathic weakness, suggesting that it may be related to the loss of functional axons.32,51 For both Hspb8K141N and Gjb1-null mice, Ncam1 elevation was evident from 6 months, and continued to increase with age in parallel with the progression of the neuropathy (Fig. 2B and C). Here, GJB1 is linked to neuropathy.