PCPE-1 deficiency had no impact on CDA HFD-induced mRNA expression of Smooth Muscle Actin, procollagen type I and LOXL-2, this result suggests that PCPE-1 is a distal player and does not seem to be involved in the regulation of expression of these markers, at least in this model (with 8 weeks of a NASH diet). The gene discussed is COL1A2; the disease is metabolic dysfunction-associated steatohepatitis.