Accordingly, MCF-7/pBABE, MCF-7/CCN1, MCF-7/D125A-CCN1, and MCF-7/TM-CCN1 cells all exhibited a mass-like morphology with disorganized nuclei and filled colony centers characteristic of luminal-like breast cancer cells [39, 40] (Figure 2D, right panels). This evidence concerns the gene CCN1 and breast carcinoma.