2010; Liu et al. 2019). Cilia and flagella associated protein 69 (Cfap69) is located in the midpiece of the sperm flagellum, and its deletion causes a variety of abnormalities in the flagella in human and mouse spermatozoa, leading to male infertility (Dong et al. 2018; He et al. 2019; Mbango et al. 2019). This evidence concerns the gene CFAP69 and male infertility.