HDAC6 and infection: To further validate thesepremises, a recent study examined theoutcome of Hdac6 depletion on both the CF inflammatoryresponse and the bacterial load in a model of infection using clinical PA isolates embedded in agarose beads, which effectivelyrecapitulates CF phenotype.18 In that study,genetic ablation was preferred over pharmacological inhibition inorder to avoid contributions ascribable to off-target effects.