CFTR and cystic fibrosis: A few years later, more direct evidencewas provided that HDAC6activity influences the levels of membrane cholesterol in CF epitheliumand that the electrochemical measurement of these levels is closelylinked to genetic and pharmacological CFTR correction.107 In particular, the evidence demonstrating thathigh cholesterol levels in CF cells are correlated with the CFTR phenotypeand depend on de novo cholesterol synthesis108−110 prompted the hypothesis of an adaptative response to the loss ofCTFR function.