Accordingly,compelling new support has been provided for isoform HDAC6 as a commonthread in the generation of the dysregulated proinflammatory and fibroticphenotype in CF.14−19 HDAC6 also plays a crucial role in bacterial clearance or killingas a direct consequence of its effects on CF immune responses.18 Inhibiting HDAC6 functions thus eventually representsa novel and effective strategy to tackle multiple aspects of CF-associatedlung disease. This evidence concerns the gene HDAC6 and cystic fibrosis.