Since TGF-β participates in the regulation of multiple signaling pathways in the body, and TGF-β is closely related to the body’s metabolism, aging, circadian rhythm, epigenetics, EMT, and other cellular processes, learning how to regulate the TGF-β signaling pathway for the treatment of fibrosis while avoiding toxic side effects has become key to drug development [68, 127–129]. The gene discussed is TGFB1; the disease is fibrosis.