Myositis-specific antibodies include antibodies directed against aminoacyl-tRNA synthetases (anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, anti-KS, anti-Ha, and anti-Zo), type 5 protein associated with melanoma (anti-MDA5), nuclear helicase (anti-Mi-2), signal recognition particle (anti-SRP), transcriptional intermediary factor 1 (anti-TIF1), nuclear matrix protein 2 (anti-NXP2), and SUMO-1 activating enzyme (anti-SAE) [1]. This evidence concerns the gene MORC3 and melanoma.