The most important features of lasso-selected models included hsa-miR-423–5p isomiR (iso-20-5KP25HFF), GBP3, and piR-hsa-28723 for all histologies; Y-RNA, hsa-miR-423–5p isomiR (iso-20-5KP25HFF), and LINC01362 for NSCLC; HIST1H4E, PTCH2, and tRF-R29P4P9L5HJVE for SCLC (Supplementary file 2). Here, PIR is linked to small cell lung carcinoma.