G3BP1 and osteosarcoma: In vivo, SGs have been implicated in metastasis, as osteosarcoma cells with knockdown of G3BP1 were associated with reduced levels of lung metastases upon implantation in the kidney capsule, compared to control osteosarcoma cells, which formed lung metastases within 4-5 weeks of implantation (Somasekharan et al., 2015).