In 2019, Tang reported 3 cases of the G41D mutation.[17] In addition, Liu et al reported 7 G41D-mutant individuals in 24 fALS cases using a screening technique.[2] He claimed that the p.G41D mutation had a higher frequency in SOD1-related Chinese patients with ALS than in the Caucasian ALS cohort, indicating a possible genotypic-geographic linkage of inherited ALS. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.