CP and heavy drinking are recognized risk factors for developing pancreatic ductal adenocarcinoma (PDAC).[1,2] The overall incidence of CP-associated PDAC remains unclear with reports of varying occurrence rates.[2,3] Intraductal papillary mucinous neoplasm (IPMN) is a distinct disease entity independent of CP, and is mucin-producing tumor of the pancreas by the papillary proliferation of atypical mucinous epithelium in the main or branched pancreatic ducts. This evidence concerns the gene MUC5AC and pancreatic intraductal papillary-mucinous neoplasm.