GRN and Cerebral ischemia: In this study, adult male C57BL/6 mice were subjected to the permanent middle cerebral artery occlusion (pMCAO) to induce cerebral ischemia, and received an intracerebroventricular (i.c.v.)administration of recombinant mouse PGRN (r‐PGRN) at 30 min after pMCAO.