Due to the amino acid replacement from Thr to Ala, which leads to a transition from A to G, the A10398G ND3 SNP may encode one subunit constituting complex I.38The mitochondrial electron transport is catalyzed by a very large enzyme complex I.39, 40The trivially correlated 10398G allele may improve the expression of complex I.12An active complex I may lead to increased ATP synthesis and defend against various PD‐related biotoxins.41 The gene discussed is MT-ND3; the disease is Parkinson disease.