Although the expressions of most symptoms were minor and transient, clinically inconsequential (except for anaphylaxis), their synchroneity, consistent direction, comparable duration, and association with rises of plasma thromboxane and anti-Comirnaty IgM provide a clear fingerprint of the CARPA tetrad, leaving no doubt about the model’s utility to study CARPA as a possible mechanism of HSRs to Comirnaty. This evidence concerns the gene CD40LG and anaphylaxis.