To address this, we crossed Hexb+/- mice (Sango et al., 1995) with the knock-in AppNL-G-F/NL-G-F AD mouse model (Saito et al., 2014), which we have previously shown to exhibit lysosomal network dysfunction, including abnormal β-hexosaminidase activity in brain homogenates (Whyte et al., 2020). This evidence concerns the gene HEXB and Alzheimer disease.