The relationship between PD-L1 expression and prognosis in GC is controversial, and although some studies reported increased PD-L1 expression associated with adverse prognosis, others have shown a relationship with better patient outcome, or report that PD-L1 expression is not a prognostic factor.49–51 Several meta-analyses have been now been performed to examine the clinicopathological and prognostic significance of PD-L1 expression. Here, CD274 is linked to gastric cancer.