CD274 and metastatic malignant neoplasm in the lymph nodes: A meta-analysis that included 10 studies and 1901 patients with GC from Asia indicated that PD-L1 expression was associated with a shorter OS.47 The expression of PD-L1 was also associated with tumor size, and lymph node metastasis, but not with age or sex, tumor differentiation, invasion depth, or tumor stage.