Histologically, CIN tumors can be of the intestinal subtype, when associated with gains in copy number of 8q, 17q, and 20q, and of the diffuse subtype, when associated with gains of 12q and 13q.20 CIN tumors are aneuploid and harbor genomic amplifications in: RTKs and KRAS, which are mutually exclusive; transcription factors, including KLF5, GATA4, GATA6, and OCT1; cell cycle mediators, including CCNE1, CCND1, and CDK6. Mutations in HER2, BRAF, EGFR, MET, FGFR2, and RAS have also been identified. The gene discussed is CCNE1; the disease is cervical squamous intraepithelial neoplasia.