BTK and endometriosis: Addressing these questions would be important to advance our understanding of the role of B cells in the normal endometrium and benign endometrial pathologies, especially in autoimmune associated reproductive pathologies, such as endometriosis, where an early study in mice demonstrated that B-cell inactivation induced by a Bruton’s tyrosine kinase (Btk) inhibitor (ibrutinib) limits endometriosis progression (Riccio et al., 2019).