Using different diagnostic methods to identify B cells, plasma cells or Igs, the reported prevalence of CE varied in the same cohort (Toth et al., 2007; Liu et al., 2018; Parks et al., 2018; Cicinelli et al., 2019; Song et al., 2019; Zargar et al., 2020). Here, CUBN is linked to cholesteryl ester measurement.