Most genes were characterised by copy number amplification, including FADS2, FTH1, NQO1, ABCC1, AKRIC2, AKRIC1, FANCD2, and AKR1C3, whereas some genes including ACSL3, GOT1, FDFT1, HMGCR, GPX4, and CRYAB were characterised by copy number deletion in bladder cancer. The gene discussed is HMGCR; the disease is urinary bladder carcinoma.