In a Phase I dose-escalation study carried out by Shah et al. (94), the authors demonstrated that in adult B-cell NHL and chronic lymphocytic leukaemia, bispecific CD19/CD20 CAR T cells were able to prevent antigen loss and achieve 64% CR and 18% partial response (PR) at day 28. This evidence concerns the gene CD19 and B-cell non-Hodgkin lymphoma.