We found tumor weight increased in Hepa1-6-shRNA1-bearing mice group (Figure 4B) and there were significantly fewer CD3+CD8+ T cells present among infiltrating immune cells (CD45+ live cells) in Hepa1-6-shRNA1 tumors compared to Hepa1-6-sh-NC tumors (Figure 4C). This evidence concerns the gene CD8A and neoplasm.