Conditions and signaling in TME of an aggressive tumor are acting mainly for suppression of anti-tumor immune cells, such as CD8+ T, macrophage type 1 (M1), and natural killer (NK) cells, while promoting the activity of pro-tumor immune cells including regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and macrophage type 2 (M2) cells. Here, CD8A is linked to neoplasm.