Importantly, the T-box transcription factor TBX3 is upregulated in sarcoma cell lines and patient-derived sarcoma tissues including fibrosarcomas, chondrosarcomas, liposarcomas and rhabdomyosarcomas, and c-Myc transcriptionally activates TBX3 to promote transition through S-phase in rhabdomyosarcoma and chondrosarcoma cells (15–17). Here, TBX3 is linked to rhabdomyosarcoma.