Furthermore, the HOTAIR/miR‐206/TBX3 axis was shown to mediate cancer stemness of ovarian CSCs (47) and pancreatic ductal adenocarcinoma CSCs express high levels of TBX3 and sustain stemness via an autocrine TBX3-ACTIVIN/NODAL signaling loop (48). Here, TBX3 is linked to pancreatic ductal adenocarcinoma.