Importantly, several of the top upregulated genes (FC > 5) were associated with sarcomagenesis (Supplementary Table 1) and 57 of the upregulated genes in TBX3 hMSCs were present in the CINSARC (Complexity INdex in SARComas) database which contains 67 genes associated with sarcoma aggressiveness and poor prognosis (44) (Table 3). This evidence concerns the gene TBX3 and sarcoma.