Since our study demonstrated that c-Myc activates TBX3 and that the overexpression of TBX3 on its own in hMSCs resulted in the regulation of a set of c-Myc target genes, it is tempting to speculate that when c-Myc is amplified/overexpressed it upregulates TBX3 which then functions as one of its key mediators to transform MSCs into sarcomas. The gene discussed is TBX3; the disease is sarcoma.