Similar to CRS related to monoclonal antibody therapy, CRS related to adoptive T cell therapy is closely associated with increases in IL-6 and TNF-α levels, accompanied by increases in IL-2, granulocyte macrophage colony stimulating factor (GM-CSF), IL-5, IL-8 and IL-10 (75–78). This evidence concerns the gene CSF2 and congenital rubella syndrome.