From the results, we recognized the negative correlation between RNF135 expression and tumor purity (Cox = 0.377, p = 3.94e−13) and the positive correlation between RNF135 expression and the infiltration of immune cells, including B cells (Cox = 0.23, p = 1.64e−05), CD8+ T cell (Cox = 0.216, p = 5.74e−05), CD4+ T cell (Cox = 0.347, p = 3.63e−11), macrophage (Cox = 0.336, p = 1.94e−10), neutrophil (Cox = 0.26, p = 9.69e−07), and dendritic cell (Cox = 0.327, p = 6.25e−10) (Figure 4D). This evidence concerns the gene CD8A and neoplasm.