As expected, in TRAIL-sensitive Huh-7 (S) and HCCLM3 (S) cells, CASC2 modulated caspase-8 and caspase-3 levels, whereas in TRAIL-resistant Huh-7 (R) and HCCLM3 (R) cells, CASC2 modulated IKKβ, p-IκBα, and p-p65 levels, indicating that CASC2 also affects TRAIL-sensitive and TRAIL-resistant HCC cells in different ways. Here, CASP3 is linked to hepatocellular carcinoma.