HOMA-IR as an index of insulin resistance and LDL/HDL ratio as a risk ratio, and serum concentrations of FFA, TNF-alpha, and IL-6 as factors involved in insulin resistance, were measured in high-fat diet/STZ-induced type 2 diabetic (HFD/STZ-induced T2D) mice. Here, IL6 is linked to type 2 diabetes mellitus.