CD274 and neoplasm: While not statistically significant, mice that received α-PD-L1 NP versus α-PD-L1 mAb showed an increase in the proportion of CD8+ T cells (26.8 versus 18.9 percent) and B cells (83.1 versus 59.5 percent) in the spleen, and a higher frequency of tumor infiltrating MHCII+Ly6C/G+F4/80+ macrophages (18.2 versus 11.7 percent), MHCII-Ly6C/G+CD11b+ neutrophils (7.3 versus 2.4 percent) and NK1.1+CD49b+ NK cells (2.5 versus 0.5 percent) in the tumor at 4 weeks post MC38 injection (Figure 5B).