CWC: cirrhosis with COVID-19; COVID-19: coronavirus disease 2019; CCI: Charlson Comorbidity Index; ACLF: acute on chronic liver failure; CLD: chronic liver disease; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; AST: aspartate transaminase; ALT: alanine transaminase; OR: odds ratio; CI: confidence interval; HR: hazard ratio. The gene discussed is GOT1; the disease is acute-on-chronic liver failure.