INS and major depressive disorder: Almost half of T1DM victims selected poison as a method of suicide, which was nearly double the rate for non-DM patients; self-poisoning was similarly more prevalent among T2DM victims compared to controls. The earliest report of high dosage of insulin use with a suicide purpose in a diabetes patient dates back to 1934 when a 50-year-old female patient used 400 units of insulin reportedly out of depression as a result of financial concerns.