CD8A and X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia: In vitro studies also proved the impaired EBV-specific cytotoxic function on both CD8 T-cells and NK cells of XMEN patients (Chaigne-Delalande et al., 2013; Li et al., 2014; Ravell et al., 2020b).