However, the adjacent nonsense variant c.110G > A has been reported in patients diagnosed with XMEN who presented with EBV viremia, inverted CD4/CD8 ratios, and decreased NKG2D expression (Li et al., 2014; Ravell et al., 2020b). Here, CD4 is linked to X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.