These experimental studies showed that lncRNAGNAS-AS1 was highly expressed in M2 Mφs and NSCLC cell lines, which was significantly higher than that in M1 Mφs, and promoted the polarization of M2 Mφs and progression of NSCLC by directly inhibiting miR4319 and increasing the level of N-terminalEF-handcalciumbindingprotein3 (NECAB3). Here, NECAB3 is linked to non-small cell lung carcinoma.