Therefore, lncRNA Xist competes with miR-101-3p to regulate the expression of C/EBPα and KLF6 to mediate Mφs polarization, promote the expression of lncRNA Xist in M1 Mφs and inhibit the expression of miR-101-3p in M2 Mφs, thus inhibiting the progression of breast cancer. This evidence concerns the gene KLF6 and breast cancer.