LDLR and atherosclerosis: According to histological and Mac-3 macrophage staining of aortic roots and aortas, the LDLR-/-ApoB100/100 mice had prominent, macrophage-rich atherosclerotic lesions, while C57Bl/6JRj mice had no signs of atherosclerosis (Figures 2, 3 and Supplementary Figures 4, 5).