The results demonstrated that multiple regulators (HDAC2, HDAC1, HAT1, HDAC11, YEATS4, SMARCA4, HDAC5, BRDT, DPF2, HDAC4, KAT7, SMARCA2, BPTF, BRD4, PBRM1, HDAC3, BRD3, DPF1) were risk factors for HCC, and only SMARCA2 was a protective factor against HCC (Figure S2A and Table S5). Here, HDAC5 is linked to hepatocellular carcinoma.