The results demonstrated that multiple regulators (HDAC2, HDAC1, HAT1, HDAC11, YEATS4, SMARCA4, HDAC5, BRDT, DPF2, HDAC4, KAT7, SMARCA2, BPTF, BRD4, PBRM1, HDAC3, BRD3, DPF1) were risk factors for HCC, and only SMARCA2 was a protective factor against HCC (Figure S2A and Table S5). This evidence concerns the gene HDAC1 and hepatocellular carcinoma.