The results demonstrated that multiple regulators (HDAC2, HDAC1, HAT1, HDAC11, YEATS4, SMARCA4, HDAC5, BRDT, DPF2, HDAC4, KAT7, SMARCA2, BPTF, BRD4, PBRM1, HDAC3, BRD3, DPF1) were risk factors for HCC, and only SMARCA2 was a protective factor against HCC (Figure S2A and Table S5). The gene discussed is PBRM1; the disease is hepatocellular carcinoma.