FOXP3 and neoplasm: Different immune cells exhibit unique distributions throughout different regions, as CD20+, CD4+, and Foxp3+CD4+ TILs were enriched in TM regions, highlighting their regulatory role in immune function as reported (21), while CD8+ TILs were more enriched in the tumor regions (TB and TM) than in the NS, suggesting their cytotoxic roles in tumor cells.