In comparison with HPV (-)HNSCC, of which 40% of the cases (140/359) were reported to have a CPS≥1, we had 73.2% (80/112) CPS≥1 cases, indicating higher PD-L1 expression in HPV(+)OPSCC than in HPV(-) counterparts (17). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.