CD8A and neoplasm: Mirroring the findings from the co-infiltrated tumor regions, TLS with high CD8+ T-cell and B-cell frequency (such as the mature-CD8high subtype) had the highest proportion of progenitor-like CD8+ T cells and PD-1+ B cells, which implies the possible role of local interactions between B cells and CD8+ T cells in immune response regulation by supporting PD-1+TCF1+ CD8+ T cells.