The activity of these cytokines translates into specific pathophysiological phenomena such as fibrosis (TGF-β), activation of B cells and plasma cells to IgG4 production (IL-10, IL-4, IL-5), and eosinophilia (Il-5, Il-4, Il-13) (30, 38). This evidence concerns the gene IL10 and Increased total eosinophil count.