It has been demonstrated that the overexpression of TLR-7 in IgG4-RD stimulates macrophages 2 to produce IL-33 which in turn stimulates Th2 response (39), which suggests that the TLR-7 level might be also considered as a biomarker of the activation of Th2 pathway and of inflammatory response. This evidence concerns the gene TLR7 and immunoglobulin G4-related sclerosing disease.