Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease in which under certain conditions, the tolerance is broken and B cells are stimulated depending on and independently of the activity of T lymphocytes, which causes their hyperreactivity and the production of antibodies mainly for ribonucleoproteins: anti-SSA (Ro52 + Ro60) and SSB/La. The gene discussed is TRIM21; the disease is Sjogren syndrome.