DHX58 and hepatitis C virus infection: Hei and Zhong (2017) showed that LGP2 could promote the production of IFN and inhibit virus replication during hepatitis C virus infection. They constructed an LGP2 K30A mutant to inactivate its ATPase activity and found that the mutant failed to induce IFN production (Hei and Zhong, 2017).