In the nucleus, the binding of exogenous DNA by IFI16 leads to the formation of IFI16-ASC-procaspase-1 inflammasome and cytoplasmic translocation, resulting in the secretion of proinflammatory cytokine IL-1β to defend against viral infection (Kerur et al., 2011; Ansari et al., 2013; Singh et al., 2013). This evidence concerns the gene IFI16 and viral infectious disease.