However, as the one of the most studied adipokines in metabolic disorders, leptin showed a paradoxical association with cardiovascular diseases in clinical studies (14); while adiponectin, a well-established anti-inflammatory adipokine, protected against cardiac hypertrophy and was found to be related to LVH in several clinical studies (15, 16), but not others (11, 17). Here, ADIPOQ is linked to cardiovascular disorder.