LEP and myeloid sarcoma: In conclusion, we found higher ANGPTL8 was associated with smaller LVM in Chinese youths at risk of MS independent of BMI and other classical cardiovascular risk factors, suggesting that hepatokine ANGPTL8 may has a beneficial effect on cardiac remolding in youth with risk for MS; moreover, we observed the adipokine leptin has a moderation effect on ANGPTL8-LVMI relationship through TG.