FGF21 and heart failure: One study included 95 elderly patients (aged 74.5 ± 11.2 years) with heart failure reported that increased FGF21 was associated with diastolic dysfunction (20), while another reported that high FGF21 level was significantly correlated with left ventricular systolic dysfunction and tended to suffer greater risks of cardiac death in an elderly Chinese population (aged 66.3 ± 10.1 years) (21).