Additional adjustments for other traditional cardiovascular disease risk factors, including fasting blood glucose, insulin resistance, lipid profiles, hs-CRP and lifestyle factors like moderate to high activity and smoking; and further other classical adipokines including leptin, adiponectin, RBP4 and hepatokine FGF21, did not materially change the significance of the associations, while the progressive trends were observed with the increasing quartiles of ANGPTL8 levels (data not shown). The gene discussed is FGF21; the disease is cardiovascular disorder.