PRKG1 and type 2 diabetes mellitus: Xue et al. (2019) suggested that empagliflozin inhibits cardiomyopathy through the SGC-CGMP-PKG pathway in mice with type 2 diabetes. Clinical trials have shown the efficiency of empagliflozin in patients with type 2 diabetes (Frampton, 2018; Xue et al., 2019).