In addition, except hyperglycemia, high lipid, insulin resistance, and hyperinsulinemia all contribute to pyroptosis in DbCM via increasing ROS (Lee and Kim, 2017; Kar et al., 2019; Urdaneta Perez et al., 2020), which is seen as a significant activator inducing the NLRP3 inflammasome. This evidence concerns the gene NLRP3 and Hyperglycemia.