Moreover, the inhibitory inputs from the LHb have been proved to involve in manipulating reward-related activities, and this function has been linked to 5-HT modulation (Teissier et al., 2015) and DA transmission (Matsumoto and Hikosaka, 2007), which can produce anxiety-like behaviors (Huang et al., 2017; Vadodaria et al., 2018). Here, LHB is linked to Anxiety.