TGFB1 and renal fibrosis: Unilateral ureteral obstruction (UUO) model is a classic model for studying renal fibrosis, Yuan et al. reported that TMP treatment could reduce the score of interstitial collagen deposition, the density of macrophages, and the mRNA expressions of TGF-β1 and CTGF in this rat model (Yuan et al., 2012).